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New! Dynamic Kinetic Simulation and Global Data Fitting Software

The KinTek Explorer is a powerful software package that will change the way you look at your kinetic data. Representing a paradigm shift in data fitting, the KinTek Explorer takes you past all the simplifying assumptions normally used in fitting kinetic data to extract mechanistic information.

Conventional data fitting requires simplifying assumptions to allow mathematical solutions of equations describing a chosen model. This is followed by fitting the data to analytical functions, replotting of observed rates and, finally, extraction of rate constants according to the assumed model. With the release of the KinTek Explorer, conventional methods of data fitting are obsolete!

Data are fit directly to the model based on numerical integration of the rate equations, and multiple experiments can be fit simultaneously!

Click here to download the Student Edition software. This software has full functionality except you cannot import your own data.

Click here to download the order form.

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This figure illustrates the fitting of time-resolved spectra using SpectraFit™, a feature provided as an add-on for Version 2.5 of KinTek Explorer. Time-resolved spectra are de-convoluted using singular value decomposition and then fit directly to a model based upon numerical integration of the rate equations with no simplifying assumptions.
These data were kindly provided by Bruce Palfey (University of Michigan) from his 2007 Biochemistry paper (Fagan, Jensen, Björnberg and Palfey (2007) Mechanism of flavin reduction in the class 1A dihydroorotate dehydrogenase from Lactococcus lactis. Biochemistry 46, 4028-4036). Data are contained in the example file Spectra_DHOD.mec.

(From the Users Manual , Cover Page.)

 

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